The FEBS journal
Dimerization-dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors.
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin-Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A F V Gonçalves, Peter Ten Dijke, David A Baker
Published: 202510.1111/febs.70312
Abstract
The NOTCH pathway is an ancient, ubiquitously expressed cell signalling system that is essential for embryonic and postembryonic cell fate control and tissue growth. It is activated via intercellular interactions between receptors and ligands express…
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