The FEBS journal
The deubiquitinating enzyme USP8 promotes tyrosine kinase inhibitors resistance in chronic myeloid leukemia by stabilizing EIF2S1 protein.
Shan Zhang, Hurong Lai, Wanwan Bao, Caifeng Liao, Jian Li
Published: 202510.1111/febs.70300
Abstract
Tyrosine kinase inhibitors (TKIs), targeted therapeutic agents, have significantly improved survival outcomes in patients with chronic myeloid leukemia (CML). However, the emergence of drug resistance remains a challenge, with the underlying mechanis…
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