Drug and alcohol reviewHumansOpioid-Related DisordersClinical Trials as TopicAlgorithmsBias
From Clinical Trials to Real-World Impact: Introducing a Computational Framework to Detect Endpoint Bias in Opioid Use Disorder Research.
Gabriel J Odom, Laura Brandt, Aaron Marker, Salvatore Giorgi, Ganesh Jainarain, H Andrew Schwartz, Larry Au, Clinton Castro, ENDPOINT Consortium
Published: 202610.1111/dar.70085
Abstract
INTRODUCTION: Clinical trial endpoints are a 'finite sequence of instructions to perform a task' (measure treatment effectiveness), making them algorithms. Consequently, they may exhibit algorithmic bias: internal and external performance can vary ac…
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