Clinical and translational sciencePaclitaxelHumansAnimalsHEK293 CellsLiver-Specific Organic Anion Transporter 1
Pacific Blue Derivatives of Paclitaxel as Fluorescent Probes of OATP1B-Type Transporters.
Mahesh R Nepal, Yue Xu, Yan Jin, Peng Hu, Xiaojun Hu, Digamber S Rane, Angelo E Andres, Eman A Ahmed, Brandon Steiger, Alex Sparreboom, Blake R Peterson, Shuiying Hu
Published: 202610.1111/cts.70484
Abstract
Paclitaxel (Taxol) is a widely used anticancer agent that undergoes extensive hepatic metabolism and that causes a debilitating, dose-limiting peripheral neurotoxicity. We previously reported that the uptake of paclitaxel in hepatocytes and dorsal ro…
Preview only. Read the full abstract at the source