Chemical biology & drug designHumansHep G2 CellsApoptosisPhosphatidylinositol 3-KinasesHSP90 Heat-Shock Proteins
Network Pharmacology-Based Analysis and In Vitro Experiments Validation Reveal Tormentic Acid Induces Apoptosis via PI3K/AKT/HSP90 Pathway in HepG2 Cells.
Jingyang Lu, Yue Qiu, Facheng Bai, Lijun Pang, Junjie Tan, Jun Deng, Yeting Lin, Jinbin Wei, Dandan Wang
Published: 202610.1111/cbdd.70239
Abstract
Tormentic acid (TA) has demonstrated potential anti-hepatocellular carcinoma (HCC) effects. This study aimed to explore the anti-HCC effect and underlying mechanisms of TA via network pharmacology, molecular docking, molecular dynamics simulation and…
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