Chemical biology & drug designNLR FamilyPyrin Domain-Containing 3 ProteinAnimalsSirtuin 1Inflammasomes
Paeoniflorin Alleviates Pulmonary Arterial Hypertension by Suppressing TRIM24-Mediated SIRT1 Ubiquitination and NLRP3 Inflammasome Activation.
Jinbo Zhang, Wenxin Zhang, Bingbing Fan, Zhiyong Yang, Zhengkun Tian, Chunhe Wang, Lizhen Shang, Zhenghui Zhang
Published: 202610.1111/cbdd.70238
Abstract
This study aimed to investigate the molecular mechanism by which tripartite motif-containing 24 (TRIM24) regulates the ubiquitination of sirtuin 1 (SIRT1) and to explore the protective effect of paeoniflorin (PF) on pulmonary arterial hypertension (P…
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