Chemical biology & drug designHumansAntineoplastic AgentsCell LineTumorIndoles
Identification and Biological Evaluation of (4H-Thieno[3,2-b]indol-3-yl)methanol as a Tumoricidal Scaffold for an Antineoplastic Agent.
Shi-Hong Zhuang, Yi-Han Chang, Hoang-Thuc Huynh, Hsin-Yi Hung, Zih-Ting Huang, Shin-Hun Juang, Sheng-Chu Kuo, Ching-Chuan Kuo, Min-Tsang Hsieh
Published: 202510.1111/cbdd.70233
Abstract
Considerable effort has been put into developing YC-1 (lificiguat), an indazole derivative with dual targets including soluble guanylate cyclase (sGC) and hypoxia-inducible factor-1 (HIF-1), as new drug molecules with increased potency. Building on o…
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