Chemical biology & drug designHumansMolecular Docking SimulationAnimalsAntineoplastic AgentsMice
Design, Synthesis, Computational Modeling and Biological Evaluation of Novel N-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)cinnamamides as Potential Covalent Inhibitors for Oncology.
Rameshwar S Cheke, Prashant S Kharkar
Published: 202510.1111/cbdd.70211
Abstract
A novel series of covalent pyrrolo[2,3-d]pyrimidine cinnamamides was synthesized and evaluated for anticancer activity. The compounds were tested against three cancer cell lines-MDA-MB-231 (triple-negative breast cancer), A549 (non-small cell lung ca…
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