Design and Synthesis of Holu-7, a Quinazolinone Derivative With an Active Stereo Geometry and Polar 2,4-Dihydroxyphenyl Group, as a Selective Anticancer Agent.

Quinazolin-4-one scaffolds offer rich anticancer chemistry but often trade potency for selectivity. Building on a tubulin-targeting lead (MJ-65), 12 new derivatives (26-37) were synthesized to dissect geometry-activity relationships and enhance the p…

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