Chemical biology & drug designIndoleamine-Pyrrole 23-DioxygenaseEnzyme InhibitorsMolecular Docking Simulation
From Pharmacophore Models to Lead Compounds: Construction and Activity Evaluation of Novel Indoleamine 2,3-Dioxygenase-1 Inhibitors.
Shiying Zhang, Anli Zhang, Bin Sun
Published: 202510.1111/cbdd.70207
Abstract
Indoleamine 2,3-dioxygenase-1 (IDO-1), as a crucial immunomodulatory target, plays a pivotal role in regulating immune function. In this study, the ligand-based pharmacophore model (HDAA) and the receptor-based pharmacophore model (HHDA) were respect…
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