Chemical biology & drug designThiadiazolesThiophenesMicrobial Sensitivity TestsDNA GyraseMolecular Docking Simulation
Synthesis and Molecular Modeling Studies of New Thiadiazole-Thiophene Compounds as Potent Antimicrobial Agents.
Nuha M Halawani, Fatimah A Alotaibi, Omer A Azher, Arwa Alharbi, Nadiyah M Alshammari, Asmaa L Alanzy, Nawaa A H Alshammari, Nashwa M El-Metwaly
Published: 202510.1111/cbdd.70192
Abstract
Eight thiadiazole-thiophene hybrids 4, 5, 6, and 7 were prepared by incorporating a thiophene ring system into the precursor 2-(cyanomethyl)-1,3,4-thiadiazole compounds 3a and 3b, through different strategic methods. The structures of these hybrids w…
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