Chemical biology & drug designProtein Kinase InhibitorsProto-Oncogene Proteins c-retHumansCell LineTumor
Design and Synthesis of 2-Aminopyrazolpyrimidopyridone Derivatives as RETV 804M and RETG 810C Kinase Inhibitors.
Jiayi Shen, Anzhi Li, Jieman Lin, Jihu Liu, Shuyu Jia, Xu Zhao, Sheng Chen, Yongdong Li
Published: 202510.1111/cbdd.70191
Abstract
Oncogenic conversion of the RET (rearranged during transfection) tyrosine kinase is associated with several cancers. The clinical therapeutic benefits of the second-generation RET inhibitor pralsetinib are greatly compromised by acquired resistance m…
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