British journal of pharmacology
TRP canonical 4 and/or 5 channel inhibition reduces aversion- and increases reward-responding in chronically stressed mice.
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo-Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R Pryce
Published: 202510.1111/bph.70305
Abstract
BACKGROUND AND PURPOSE: Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve u…
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