British journal of pharmacology
Molecular glue neferine induces BAP31 homodimerisation to disrupt endoplasmic reticulum-mitochondria crosstalk for anti-neuroinflammation in ischaemic stroke.
Ya-Xuan Zhu, Zhuo Yang, Ling Li, Ze-Kun Chen, Fang-Fang Zhuo, Yu-Hui Wang, Zheng-Ping Liu, Bo Han, Wei Yu, Peng-Fei Tu, Tian-Tian Wei, Hua Wang, Ke-Wu Zeng
Published: 202510.1111/bph.70277
Abstract
BACKGROUND AND PURPOSE: B-cell receptor-associated protein 31 (BAP31), an endoplasmic reticulum (ER)-resident transmembrane protein, has emerged as a critical regulator of immune cell activation, yet its role in neuroinflammation remains unexplored.…
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