British journal of pharmacology
Activation of the pentose phosphate pathway flux by hydrogen peroxide is not regulated by NADPH-mediated feedback inhibition.
Camila Aburto, Valentina Parada-Goddard, Alejandro San Martín
Published: 202510.1111/bph.70246
Abstract
BACKGROUND AND PURPOSE: Oxidative stress induces a rerouting of metabolic flux from glycolysis to the pentose phosphate pathway. One proposed mechanism involves negative feedback via tonic inhibition of glucose-6-phosphate dehydrogenase by NADPH. How…
Preview only. Read the full abstract at the source