British journal of pharmacology
An intracellular recombinant single-chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors.
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O Nikolaev, Sergei D Rybalkin
Published: 202510.1111/bph.70221
Abstract
BACKGROUND AND PURPOSE: Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho-)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cel…
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