British journal of pharmacology
Euphorbia pekinensis glycosphingolipids disrupt gut motility and fluid balance via TRPA1 activation in enterochromaffin cells.
Jie Cao, Bingbing Liu, Sheng Li, Zhican Cheng, Kou Zhang, Yanqing Xu, Yuxin Gu, Min Zeng, Changli Shen, Xin Li, Ronglu Yu, Xiaobin Cui, Huimin Bian, Xingde Zhang, Hao Wu
Published: 202510.1111/bph.70219
Abstract
BACKGROUND AND PURPOSE: Euphorbia pekinensis (EP) is known to cause significant intestinal toxicity, primarily manifesting as severe diarrhoea, yet the precise molecular mechanisms and the active components responsible have remained elusive. This stu…
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