British journal of haematology
The PINNACLE study: A multicentre phase II trial of nilotinib in combination with pegylated interferon-α2b in newly diagnosed chronic phase chronic myeloid leukaemia.
David T Yeung, Andrew P Grigg, John Reynolds, Susan Branford, Deepmala Mazumdar, Ilona Cunningham, Jake Shortt, Philip Rowlings, Rosemary Harrup, David M Ross, David Kipp, Anthony K Mills, Christopher K Arthur, Anthony Schwarer, Kathryn Jackson
Published: 202510.1111/bjh.70276
Abstract
We evaluated the tolerability and efficacy of pegylated interferon alfa-2B (peg-IFNα; PegIntron, MSD) combined with nilotinib in the Australasian Leukaemia and Lymphoma Group CML11 (Pinnacle) study. This phase II study started patients on nilotinib 3…
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