British journal of haematologyHumansLeukemiaLymphocyticChronicB-Cell
CLL-like stereotyped BCRs are equally produced in young and old healthy adults, share features of public clonotypes and may be stuck at a pre-germinal centre stage.
Marine Dupont, Paco Derouault, Virginie Pascal, Nataliya Dmytruk, Maxime Roubinet, Charlotte Rivière, Milène Parquet, Kenza Guiyedi, Melanie Boulin, Sophie Peron, Jasmine Chauzeix, Nathalie Gachard, Jean Feuillard, David Rizzo
Published: 202610.1111/bjh.70204
Abstract
Chronic lymphocytic leukaemia (CLL) is a B-cell lymphoproliferative disorder with ~40% of cases harbouring stereotyped B-cell receptors (BCRs), defined by common features in their immunoglobulin sequences. Major CLL stereotypes are associated with sp…
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