British journal of haematologyHumansLymphomaT-CellHistone Deacetylase InhibitorsAnimals
Geranylgeranyl transferase-1 inhibitor GGTI-2417 enhances the anti-tumour efficacy of histone deacetylase inhibitors in different T-cell lymphoma lines.
Xiaoyan Hu, Lin Li, Jewel Nkwocha, Hitesh Vasiyani, Aslamuzzaman Kazi, Said Sebti, Steven Grant
Published: 202510.1111/bjh.70188
Abstract
Histone deacetylase inhibitors (HDACIs) are approved for T-cell lymphoma (TCL) treatment, but resistance represents a major problem. Recent encouraging clinical activity of the geranylgeranyl transferase inhibitor GGTI-2418 (PTX-100) in TCL prompted…
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