Acta physiologica (Oxford, England)AnimalsInsulin-Secreting CellsGlucagon-Like PeptidesMiceMale
Effect of Weight-Neutral Treatment With Semaglutide or Tirzepatide on β-Cell Identity in db/db Mice.
Zhaobin Deng, Dongxu Zheng, Jinsook Son, Wen Du, Wendy M McKimpson, Qingli Liu, Domenico Accili
Published: 202610.1111/apha.70141
Abstract
AIM: Insulin resistance and pancreatic β-cell failure are key characteristics of type 2 diabetes (T2D). Impaired β-cell function is associated with loss of β-cell identity, resulting in β-cell dedifferentiation or trans-differentiation to other endoc…
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