Clinical and experimental pharmacology & physiologyMicroRNAsArthritisRheumatoidHumansAnimals
METTL3-Mediated m6A Modification Facilitates pri-miR-221 Maturation to Regulate Macrophage M1/M2 Polarisation and Immune Inflammation in Rheumatoid Arthritis.
Xiangping Gong, Wei Li, Xiaohui Wu, Lirong Mao
Published: 202610.1111/1440-1681.70099
Abstract
OBJECTIVE: Rheumatoid arthritis (RA) pathogenesis involves dysregulated macrophage polarisation, yet the epigenetic mechanisms governing this process remain poorly understood. This study investigates how METTL3 promotes pri-miR-221 maturation via m6A…
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