Clinical and experimental pharmacology & physiologyCisplatinPeroxiredoxin VIAnimalsAcute Kidney InjuryMice
Exploring the Protective Role and Regulation of Prdx6 in Cisplatin-Induced AKI.
Xianzhe Li, Jinbo Yu, Shi Cheng, Yaqiong Wang, Xiaoqiang Ding
Published: 202610.1111/1440-1681.70093
Abstract
Cisplatin (CDDP) is a widely used chemotherapeutic agent that induces nephrotoxicity by generating excessive reactive oxygen species (ROS), leading to oxidative stress, inflammation and apoptosis in renal proximal tubular cells. Peroxiredoxin 6 (Prdx…
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