Clinical and experimental pharmacology & physiologyAnimalsDexmedetomidineMiceSleep DeprivationSignal Transduction
Dexmedetomidine Alleviates Sleep Rhythm Abnormalities in Chronic Sleep-Deprived Mice via Modulation of SIK3/HDAC4/5 Signalling.
Zhengye Wang, Yitong Ding, Yonghong Zhou, Zhouquan Wu
Published: 202610.1111/1440-1681.70086
Abstract
BACKGROUND: Sleep deprivation (SD) often disrupts normal sleep patterns, leading to anxiety-like behaviours and cognitive impairments. Dexmedetomidine (DEX), a highly selective α-2 adrenergic agonist, has been reported to improve postoperative sleep…
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