Absence of cortical reorganization following an internal capsule stroke in rodents.

Stroke is a leading cause of disability, causing chronic motor impairments in many survivors. Although recovery is correlated with cortical reorganization, the impact of lesion location on post-stroke reorganization is uncertain. We compared movement-related neural activity following experimental infarcts to the motor cortex (M1) or internal capsule in rats. Neural activity was recorded from motor and somatosensory regions during a skilled pellet retrieval task longitudinally during the course of recovery. Cortical lesions resulted in early behavioral recovery accompanied by widespread reductions in neural activity across ipsilesional regions, indicative of large-scale reorganization. In contrast, internal capsule lesions produced delayed recovery with no evidence of long-term ipsilesional cortical reorganization. These findings challenge the relevance of cortical reorganization for recovery from subcortical lesions and indicate that post-stroke recovery mechanisms are lesion-specific and that models targeting subcortical white matter are essential for maximizing translational relevance.