Microbial genomicsNanopore SequencingDNA MethylationReproducibility of ResultsHigh-Throughput Nucleotide SequencingSequence Analysis
Reproducibility and accuracy of bacterial methylome profiling using Oxford Nanopore Technologies nanopore sequencing platform.
Taylor Schababerle, Omar Hayat, Jaeone Jung, Minh Le, Isabella Polic, Hanan Wees, Micah Bhatti, Samuel Shelburne, Xiaojun Liu, Awdhesh Kalia
Published: 202510.1099/mgen.0.001564
Abstract
Background. Oxford Nanopore Technologies (ONT) enables direct methylome profiling using the Dorado basecaller, but the comparative performance of ONT-only versus hybrid-assembly reference-based methylation calling, particularly regarding inter-operat…
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