Open biologyHumansMutagenesisDNA ReplicationTrinucleotide RepeatsNucleotidyltransferases
REV1 inhibition enhances trinucleotide repeat mutagenesis.
Ava Siegel, Daniel Almstead, Naveen Kothandaraman, Jessica Reich, Erica Lamkin, Joshua Victor, Aarzoo Grover, Kanayo Ikeh, Hannah Koval, Andrew Crompton, Hongjun Jang, Hyejin Lee, Roxana Del Rio-Guerra, Dmitry Korzhnev, M Kyle Hadden
Published: 202510.1098/rsob.250234
Abstract
Trinucleotide repeat instability has been implicated in the pathogenesis of numerous neurodegenerative disorders. While germline expansions destabilize trinucleotide repeats to cause disease anticipation, somatic cell trinucleotide repeat instability…
Preview only. Read the full abstract at the source