Pain
The impact of opioid withdrawal symptoms on pain outcomes in enriched enrollment randomized withdrawal trials: a mediation meta-analysis of trials submitted to the US Food and Drug Administration.
Christopher J Miller, Andrew Conroy, Warren B Bilker, Alisa J Stephens-Shields, John T Farrar
Published: 202510.1097/j.pain.0000000000003895
Abstract
ABSTRACT: The validity of enriched enrollment randomized withdrawal (EERW) trials to evaluate the efficacy of opioids for the treatment of chronic pain has been questioned. Enriched enrollment randomized withdrawal trials include an open-label titrat…
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