Alzheimer disease and associated disordersHumansAlzheimer DiseaseFibronectinsUnited KingdomMale
rs140926439 Variant in the Fibronectin FN1 Gene Lowers Risk of Alzheimer Disease in APOEε4 Carriers in the UK Biobank Cohort.
Steven Lehrer, Peter H Rheinstein
Published: 202510.1097/WAD.0000000000000692
Abstract
BACKGROUND: A genetic variant in the fibronectin FN1 gene reduces the odds of developing AD by up to 70%. This variant, rs140926439, appears to prevent the buildup of excess fibronectin at the blood brain barrier. Increased fibronectin levels are typ…
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