Transplantation
Improved DCD Heart Transplant Function Through Ferroptosis Blockade in a Model of Experimental Normothermic Ex Vivo Perfusion.
Xuan Pan, Jianqiang Ji, Zekai Huang, Chuangjie Niu, Liwei Xu, Qinbao Peng, Xiu Liu, Shaoyi Zheng, Jun Lu, Zhong Zhang, Pengyu Zhou
Published: 202610.1097/TP.0000000000005606
Abstract
BACKGROUND: Adopting donation after circulatory death (DCD) hearts can increase the donor pool. However, DCD hearts experience severe ischemia-reperfusion injury (IRI). Ferroptosis is a key contributor to organ IRI. Liproxstatin-1 (Lip-1), a selectiv…
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