TransplantationAnimalsImmunosuppressive AgentsKidney TransplantationTransplantationHeterologous
Proteinuria Remains a Significant Hurdle to Successful Pig Kidney Xenotransplantation Despite an Effective Immunosuppressive Regimen.
Kohei Kinoshita, Akihiro Maenaka, Maho Terashita, Ivy A Rosales, Yuji Hidaka, Gweneth Eliza Lavalla, Madelyn Ma, Zahra Habibabady, David Ayares, Seth Lederman, Robert B Colvin, Richard N Pierson, Tatsuo Kawai, David K C Cooper
Published: 202610.1097/TP.0000000000005508
Abstract
BACKGROUND: This study evaluated the efficacy of an optimized immunosuppressive regimen, including a higher dose of anti-CD154 monoclonal antibody (TNX-1500), in prolonging graft survival in pig-to-baboon kidney xenotransplantation. Despite advances…
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