Shock (Augusta, Ga.)
Chromatin Remodeling and Transcriptional Silencing Define the Dynamic Innate Immune Response of Tissue Resident Macrophages After Burn Injury.
Han G Kim, Marie-Pierre L Gauthier, Aidan Higgs, Denise A Hernandez, Mingqi Zhou, Jason O Brant, Rhonda L Bacher, Dijoia B Darden, Shannon M Wallet, Clayton E Mathews, Lyle L Moldawer, Philip A Efron, Michael P Kladde, Robert Maile
Published: 202510.1097/SHK.0000000000002746
Abstract
Severe burn injury induces prolonged immune dysfunction, but the underlying molecular mechanisms remain poorly defined. We hypothesized that burn injury causes epigenetic and transcriptional training of innate immune cells. Splenic F4/80⁺ macrophages…
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