Shock (Augusta, Ga.)AnimalsDichloroacetic AcidMiceSepsisPyruvate Dehydrogenase Complex
Pyruvate Dehydrogenase Complex Stimulation With Dichloroacetate May Improve Septic Cardiac Dysfunction.
Lane M Smith, Yu Tin Lin, Chelsey S Mertens, Manal L Zabalawi, David L Long, Barbara K Yoza, Anderson O Cox, Boone M Prentice, Peter W Stacpoole, Charles E McCall
Published: 202510.1097/SHK.0000000000002642
Abstract
BACKGROUND: Cardiomyopathy is a common complication of sepsis that contributes to increased morbidity and mortality. However, the molecular mechanisms underlying septic cardiomyopathy are poorly understood. Dichloroacetate (DCA) improves mitochondria…
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