Characteristics associated with breakthrough congenital syphilis in Florida and Arizona, 2018-2022.

ABSTRACT: Congenital syphilis (CS) can occur despite timely identification and adequate treatment of maternal syphilis (breakthrough CS). We examined associations between maternal characteristics and prevalence of breakthrough CS. Having primary/secondary syphilis, a higher maximum non-treponemal titer, and treatment initiation closer to delivery were associated with higher prevalence of breakthrough CS.