OGT-mediated O-GlcNAcylation of ATF3 Transcriptionally Activates ACSL1 to Aggravate Ferroptosis in Severe Acute Pancreatitis: ATF3 O-GlcNAcylation Promotes SAP Ferroptosis.

BACKGROUND: Acute pancreatitis (AP) is a common cause of acute abdominal pain, and about 25% of AP patients will develop severe acute pancreatitis (SAP), causing damage to multiple organ functions and eventually death. Ferroptosis has recently been i…

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