How PCORnet® Could Advance Postmarket Evidence Generation.

The PCORnet vision to accelerate progress towards a learning health system by enabling more efficient generation of evidence is shared by the US Food and Drug Administration, where we recently served. One way of achieving this goal is to develop national networks capable of running streamlined clinical trials in the postmarket setting. In this invited commentary, we discuss how PCORnet® and similar networks could facilitate streamlined trials integrated into clinical practice across their sites.