Recurrent gastric solitary Peutz-Jeghers polyp after endoscopic treatment: A case report and literature review.

RATIONALE: Solitary Peutz-Jeghers polyp (SPJP) is a rare hamartomatous polyp that histologically mimics polyps seen in Peutz-Jeghers syndrome but occurs in isolation, without the associated mucocutaneous pigmentation, intestinal polyposis, or family history. Gastric involvement is exceedingly uncommon, with only 16 cases documented worldwide. This report aims to contribute a novel case that highlights a previously unreported clinical course for this rare entity. PATIENT CONCERNS: A 49-year-old Chinese female presented with a primary complaint of abdominal distension. DIAGNOSES: Recurrent gastric SPJP. INTERVENTIONS: The patient underwent 2 separate endoscopic submucosal dissection procedures. The first was for the initial resection of the antral polyp, and the second was performed 1 year later to remove the recurrent polyp at the original site. OUTCOMES: Both endoscopic submucosal dissection procedures were completed successfully without any immediate or periprocedural complications. The patient recovered well following each intervention. The pathological diagnosis of a Peutz-Jeghers hamartomatous polyp was consistent after both resections. LESSONS: This case represents the first documented instance of a recurrent gastric SPJP. It demonstrates that even solitary, sporadic Peutz-Jeghers polyps may have a potential for recurrence. Therefore, we recommend complete endoscopic or surgical resection of these polyps, followed by stringent endoscopic surveillance to facilitate the early detection and management of recurrence. This finding provides crucial insight for the management and follow-up strategy of this rare condition.