Hepatology (Baltimore, Md.)
KLF9 drives intermittent hypoxia-induced MASLD by suppressing the NR4A1-p38 MAPK hepatic metabolic axis.
Hongting Hua, Dong Wang, Lanqiaofeng He, Nuo Chen, Zongshi Gao, Xiaonan Yang, Dongyu Si, Xiang Wei, Lei Zhang, Wanjin Jiang, Jingya Gao, Miao Zhang, Hongli Wang, Gong-Hong Wei, Huabing Zhang
Published: 202510.1097/HEP.0000000000001606
Abstract
BACKGROUND AND AIMS: Obstructive sleep apnea (OSA), characterized by recurrent episodes of intermittent hypoxia (IH), is increasingly recognized as a contributor to metabolic disorders, including metabolic dysfunction-associated steatotic liver disea…
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