Hepatology (Baltimore, Md.)
The development of a pan-genotypic T cell vaccine against hepatitis C virus using heterologous prime-boost strategies.
Rebecca Strain, Matthew Edmans, Gerardo Montalvo Zurbia-Flores, Nicole Frumento, Anthony Brown, Claire Hutchings, Callum Board, Chanice Knight, Andrew I Flyak, Justin Bailey, Georg Lauer, Andrea Cox, Paul Klenerman, Eleanor Barnes
Published: 202510.1097/HEP.0000000000001599
Abstract
BACKGROUND AND AIMS: An effective vaccine against hepatitis C virus (HCV) infection is required to achieve viral eradication. A previous viral vectored vaccine encoding a genotype-1b T cell antigen suppressed peak viral RNA but failed to prevent chro…
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