Hepatology (Baltimore, Md.)
Hepatocyte-derived extracellular vesicles promote endothelial dedifferentiation in chronic liver disease through the miR-153-3p-pyroptosis axis.
Laia Abad-Jordà, María Andrés-Rozas, Ana Martínez-Alcocer, Jessica Aspas, Yiliam Fundora, Sonia Fernández-Veledo, Carmen Peralta, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Jordi Gracia-Sancho
Published: 202510.1097/HEP.0000000000001567
Abstract
BACKGROUND AND AIMS: Liver cells communicate paracrinally through extracellular vesicles (EVs). This study investigated the role of microRNAs (miRNAs) embedded in hepatocyte-derived EVs (hepEVs) modulating endothelial cell dedifferentiation in chroni…
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