Hepatology communicationsAnimalsNatural Killer T-CellsAntigensCD1dMice
Natural Killer T cells promote cholestatic liver disease independent of antigen presentation by cholangiocytes.
Laura Valestrand, Kathrine S Nordhus, Thierry Claudel, Jonas Øgaard, Anna Frank, Enya Amundsen-Isaksen, Claudia Fuchs, Natalie L Berntsen, Brian K Chung, Xiaojun Jiang, Michael Trauner, Espen Melum
Published: 202610.1097/HC9.0000000000000862
Abstract
BACKGROUND: Natural killer T (NKT) cells are an important lymphocyte subset in the liver that can be activated by CD1d-restricted lipid antigens presented on cholangiocytes, including lipids in bile from patients with chronic liver diseases. We hypot…
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