Therapeutic drug monitoring
Metabolite Profiles of Sertraline in Relation to Genotype-Predicted Phenotypes of CYP2B6 and CYP2C19-A Study on 470 Patients.
Line S Bråten, Birgit M Tovik Wollmann, Espen Molden, Marianne K Kringen
Published: 202610.1097/FTD.0000000000001435
Abstract
OBJECTIVES: Sertraline is one of the most prescribed selective serotonin reuptake inhibitors. Pharmacokinetic variability of sertraline is extensive and primarily determined by metabolism mediated by the polymorphic enzymes CYP2C19 and CYP2B6. Howeve…
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