Pharmacogenetics and genomicsHumansDNA MethylationMalePolymorphismSingle Nucleotide
No interaction between genetic variants and DNA methylation of the ferrochelatase gene in relation to antituberculosis drug-induced liver injury.
Fei Wang, Meiling Zhang, Yu Wu, Jingru Cheng, Ruina Chen, Hongqiu Pan, Lihuan Lu, Xiaomin He, Honggang Yi, Shaowen Tang
Published: 202610.1097/FPC.0000000000000583
Abstract
OBJECTIVE: The pathogenic mechanisms of antituberculosis drug-induced liver injury (AT-DILI) remain unclear. Isoniazid and rifampicin may lead to hepatic accumulation of protoporphyrin IX in which heme synthesis ferrochelatase (FECH), a key rate-limi…
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