Behavioural pharmacology
Wortmannin, a potent phosphatidylinositol 3-kinase inhibitor, suppresses methamphetamine-induced stereotypy and hyperlocomotion in mice.
Takahiro Hamana, Nobue Kitanaka, Frank Scott Hall, Kotoko Amagata, Kentaro Matsuda, Chiaki Morita, Masanori Nakai, Riko Niki, Sho Yuze, Kazuo Tomita, Kento Igarashi, Tomoaki Sato, George R Uhl, Junichi Kitanaka
Published: 202610.1097/FBP.0000000000000871
Abstract
Phosphatidylinositol 3-kinase (PI3K) (EC2.7.1.137) is an enzyme essential for a variety of biological processes, including inflammation and neuroplasticity. There is a close, positive relationship between these biological functions and the action of…
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