Epidemiology (Cambridge, Mass.)
Test-negative designs with various reasons for testing: statistical bias and solution.
Mengxin Yu, Tom Hongyi Liu, Kendrick Qijun Li, Nicholas Jewell, Eric Tchetgen Tchetgen, Dylan Small, Xu Shi, Bingkai Wang
Published: 202510.1097/EDE.0000000000001940
Abstract
Test-negative designs are widely used for post-market evaluation of vaccine effectiveness, particularly in cases when randomized trials are not feasible. Unlike classical test-negative designs, which only include healthcare seekers with symptoms, rec…
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