American journal of clinical oncology
A Phase 2 Trial of Protein Kinase C Iota Inhibition With the Combination of Auranofin and Sirolimus in Patients With Recurrent Ovarian Cancer.
Aminah Jatoi, Nathan R Foster, Andrea Wahner Hendrickson, Matthew S Block, S John Weroha, Erik J Asmus, Nicole R Murray, Alan P Fields
Published: 202510.1097/COC.0000000000001263
Abstract
OBJECTIVES: This trial served as a proof-of-concept for whether inhibition of protein kinase C iota (PKCι) with auranofin and sirolimus provide antineoplastic effects in patients with recurrent high-grade serous ovarian cancer. METHODS: This drug com…
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