Chinese medical journal
Single-cell and spatial transcriptomics reveal the interaction between PRRX2-driven epithelial cells and SPP1+ macrophages in mediating gemcitabine resistance in pancreatic ductal adenocarcinoma.
Jingmei Liu, Zhilong Li, Guanhua Liu, Zhihua Pei, Weilin Liu, Wenhui Yang, Feng Li, Lijuan Huo
Published: 202510.1097/CM9.0000000000003966
Abstract
BACKGROUND: The development of gemcitabine resistance significantly diminishes treatment efficacy and worsens prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). A comprehensive understanding of the molecular and cellular mechanisms d…
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