Journal of immunotherapy (Hagerstown, Md. : 1997)
Immunoregulatory Cyclophilin A Reprograms the Tumor Immune Microenvironment by Changing the Activation and Exhaustion Profile of T Cells and NK Cells in the Model of Melanoma B16 in Vivo.
Anastasiia Kalinina, Leila R Tilova, Dmitry Kazansky, Ludmila Khromykh
Published: 202510.1097/CJI.0000000000000586
Abstract
Cold tumors have an immunosuppressive microenvironment (TME) with weak infiltration of functionally active NK and T cells. Such tumors poorly respond to immunotherapies, and different combined approaches are investigated to reprogram cold tumors into…
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