FASEB journal : official publication of the Federation of American Societies for Experimental BiologyHumansMEF2 Transcription FactorsEndoplasmic Reticulum StressApoptosisMultiple Myeloma
USP4, Transcriptionally Activated by MEF2A, Protects Multiple Myeloma Cells From Endoplasmic Reticulum Stress-Mediated Apoptosis via Repressing NR4A1 Ubiquitination.
Jie Lin, Fanlin Zeng, Zhiyuan Zhang, Liping Liu, Zhenshu Xu
Published: 202510.1096/fj.202502043R
Abstract
Multiple myeloma (MM) remains an uncurable hematologic cancer due to neoplastic proliferation of plasma cells. The role and detailed mechanisms of Ubiquitin-Specific Protease 4 (USP4) in MM remain to be clarified. Cell viability and apoptosis were ev…
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