FASEB journal : official publication of the Federation of American Societies for Experimental BiologyAnimalsFolic AcidMiceFemaleOocytes
Differential Effects of Folic Acid and 5-Methyltetrahydrofolate on Mice Oocytes and Embryo Development In Vitro and In Vivo: Implications for Reproductive Health.
Fatemeh Nasr-Esfahani, Farnoosh Jafarpour, Shiva Rouhollahi Varnosfaderani, Mohsen Rahimi Andani, Mehdi Hajian, Negin Kazemi, Maurizio Dattilo, Mohammad Hossein Nasr-Esfahani
Published: 202510.1096/fj.202501768R
Abstract
Folic acid (FA) is widely used to support one-carbon metabolism; however, at high doses, it can circulate predominantly as unmodified FA (UMFA), potentially leading to metabolic imbalances and adverse effects on reproductive performance. This study a…
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